成骨PCR基因芯片 Osteogenesis PCR Array
成骨PCR基因芯片可用于研究与成骨细胞分化相关的84个基因的表达。该芯片包含与骨骼系统发育以及骨矿物质代谢有关的基因，包括：生长因子，参与成骨细胞的生成、生长、增殖和分化过程的基因，参与骨骼发育的细胞外基质分子和细胞粘附分子。利用实时定量PCR，研究者可以方便并且可信地分析与成骨细胞分化有关基因的表达。
Skeletal Development: Cartilage Condensation: BMP1, BMPR1B, COL2A1, SOX9. Ossification: ACVR1, AHSG, BGLAP (Osteocalcin), BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMPR1A, BMPR1B, BMPR2, CDH11, CHRD, COL1A1, COL2A1, CSF1 (MCSF), CTSK, DLX5, EGFR, FGF2 (bFGF), FGFR2, GDF10 (BMP3B), GLI1, IGF1, IGF1R, IGF2, IHH, MMP2, MMP8, MMP9, NOG, RUNX2, SMAD1, SMAD3, SOX9, SP7, SPP1 (Osteopontin), TGFB1, TGFB2, TGFB3, TNFSF11, TWIST1. Osteoclast Differentiation: BGLAP (Osteocalcin), CSF1 (MCSF), TNF, TNFSF11. Osteoblast Differentiation: ACVR1, BGLAP (Osteocalcin), BMP2, BMP4, BMP6, BMP7, BMPR1A, BMPR1B, BMPR2, CHRD, COL1A1, DLX5, FGF2 (bFGF), FGFR2, GDF10 (BMP3B), GLI1, IGF1, IHH, NOG, RUNX2, SMAD1, SMAD3, SP7, SPP1 (Osteopontin), TWIST1. Other Genes: ALPL, COMP, FGFR1, TGFBR1, TGFBR2. Bone Mineral Metabolism: Bone Mineralization: ACVR1AHSG, BGLAP (Osteocalcin), BMP2, BMP4, BMP6, BMP7, BMPR1A, BMPR1B, BMPR2, FGFR2, IGF1, SMAD3, SOX9, TGFB1, TGFB3, TWIST1. Calcium Ion Binding and Homeostasis: ANXA5, BGLAP (Osteocalcin), CALCR, CDH11, COMP, EGF, FGF2 (bFGF), ITGB1, MMP2, MMP8, TGFB1, VDR. Extracellular Matrix (ECM) Molecules: Collagens: COL10A1, COL14A1, COL15A1, COL1A1, COL1A2, COL2A1, COL3A1, COL5A1. ECM Protease Inhibitors: AHSG, SERPINH1. ECM Proteases: CTSK, MMP10, MMP2, MMP8, MMP9, PHEX. Other Genes: ALPL, BGN, FLT1. Cell Adhesion Molecules: Cell-Cell Adhesion: BMP1, BMPR1B, CDH11, COL14A1, COL2A1, EGFR, ICAM1, IHH, ITGB1, SOX9, TGFB1, TNF, TNFSF11, VCAM1. Cell-Matrix Adhesion: CD36, COL3A1, CSF1 (MCSF), ITGA1, ITGA2, ITGA3, ITGAM, ITGB1, SMAD3. Other Genes: BGLAP (Osteocalcin), COL15A1, COL5A1, COMP, FN1, TNF. Growth Factors: CSF2 (GM-CSF), CSF3 (GCSF), EGF, FGF1, FGF2 (bFGF), GDF10 (BMP3B), IGF1, IGF2, PDGFA, VEGFA, VEGFB. Transcription Factors: GLI1, NFKB1, RUNX2, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SOX9, TWIST1. |
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