EGF/PDGF信号通路PCR芯片 EGF/PDGF Signaling PCR Array
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EGF/PDGF信号通路PCR芯片可用于研究与EGF/PDGF信号通路转导有关的84个基因的表达。该芯片包含的基因编码表皮生长因子（EGF）和血小板源生长因子（PDGF）信号通路家族；代表的基因包括生长因子及其受体、参与生长因子信号下游的蛋白，生长因子介导的激活靶基因。MAP激酶途径，AKT/PI3K通路和其他下游级联信号的家族成员都包括在该芯片上。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测与EGF/PDGF信号通路有关的基因表达。 Epidermal Growth Factor Receptor Signaling Pathway: BCAR1, CBL, EGF, EGFR, EPS8, GAB1, GRB2, HBEGF, NCK2, NUP62, RPS6KA5, SHC1. Platelet-Derived Growth Factor Receptor Signaling Pathway: BCAR1, PDGFA, PDGFB, PDGFRA, PLAT. Intracellular Signaling Molecules: AKT Signaling Pathway: AKT1, AKT2, AKT3, BAD, CASP9, CHUK, FASLG, FOXO3, NFKB1, PTEN. Erk1 / Erk2 MAPK Signaling Pathway: EGFR, ELK1, GRB2, MAP2K1, MAPK1, MAPK3, MKNK1, PDGFRA, RAF1, RPS6KA5, SHC1, SRC, STAT3. IκB Kinase / NFκB Cascade: CHUK, FASLG, GSK3A, GSK3B, NUP62, RHOA, STAT1. JAK / STAT Cascade: EPS8, GAB1, GRB2, JAK1, NUP62, PPP2CA, SRC, STAT1, STAT3, STAT5A. JNK Cascade: MAP2K4, MAP3K2, MAPK10, MAPK8, MAPK9. MAPKKK Cascade: DUSP1, DUSP6, EGF, EGFR, MAP2K1, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, PPP2CA, PRKCA, SHC1. PI3K / Phosphoinositide 3-kinase Cascade: PIK3CA, PIK3R1, PIK3R2, PTEN. Small GTPase Mediated Signal Transduction: GRB2, HRAS, NRAS, NUP62, RAP1A, RASA1, RHOA. Other Intracellular Signaling Molecules: ARAF, BRAF, CBL, CSNK2A1, CSNK2B, IKBKB, NCK2, PDPK1, PLCG1, RPS6KB1. Cell Survival and Growth: Apoptosis: AKT1, BAD, BCAR1, BCL2, BRAF, CASP3, CASP9, FASLG, FOXO3, IL2, LTA, MAPK1, NFKB1, NUP62, PIK3R2, PPP2CA, PRKCA, PTEN, RAF1, RASA1, STAT1, TP53. Cell Cycle: BCL2, CCND1, DUSP1, DUSP6, EGFR, HRAS, KRAS, MAPK1, MAPK3, NRAS, PDGFA, PDGFB, PPP2CA, PRKCA, PTEN, RAP1A, SHC1, STAT1, TP53. Cell Differentiation: FOXO3, IL2, PPP2CA, TP53. Cell Growth: BCAR1, CCND1, EGF, HBEGF, IL2, PDGFA, PDGFB, PDGFRA, PPP2CA, RASA1, SHC1, TP53. Cell Motility: ACTR2, BCAR1, EGFR, FN1, HBEGF, MAP2K1, MAPK8, PTEN, STAT3. Cell Proliferation: BCAR1, BCL2, EGF, EGFR, EPS8, GAB1, HBEGF, IL2, NCK2, NUP62, PDGFA, PDGFB, PDGFRA, PTEN, RAF1, SHC1, TP53. Metabolism DNA Metabolism: ATF1, ATF2, CREB1, EGF, EGFR, FOS, NUP62, PPP2CA, TP53. Lipid Metabolism: ARAF, BRAF, PIK3R1, PLCG1, PPP2CA, PRKCA, PTEN, RAF1, SHC1. Protein Metabolism: ACTR2, AKT1, AKT2, AKT3, ARAF, ATF1, ATF2, BRAF, CBL, CHUK, CREB1, CSNK2A1, DUSP1, DUSP6, EGFR, FOS, GSK3A, GSK3B, IKBKB, JAK1, MAP2K1, MAP2K4, MAP2K7, MAP3K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, PDGFRA, PDPK1, PPP2CA, PRKCA, PTEN, RAF1, RPS6KA5, RPS6KB1, SRC. Other Genes Related to Metabolism: COL1A1, EIF4E, FN1, MMP7, RASA1. Development: BRAF, COL1A1, HBEGF, PTEN, RASA1, STAT3. Response to Stimulus: Response to Wounding: BCAR1, BCL2, FN1, HBEGF, IL2, NCK2, NFKB1, PDGFB, STAT3. Response to Other Stimuli: AKT1, CHUK, COL1A1, DUSP1, EGFR, FASLG, FOS, KRAS, LTA, MAP2K1, MAP2K7, MAPK1, MAPK8, MAPK9, NFATC3, PPP2CA, RPS6KA5, STAT1, STAT5A, TP53. Transcription Factors and Regulators: AKT1, ATF1, ATF2, CBL, CREB1, EGR1, EIF4E, ELK1, FOS, FOXO3, IKBKB, JUN, MKNK1, NFATC3, NFKB1, NUP62, PPP2CA, RPS6KA5, STAT1, STAT3, STAT5A, TP53. Actin and Calcium Ion Homeostasis: ACTR2, BCAR1, CBL, EGF, EGFR, MMP7, NCK2, PDPK1, PLCG1, PRKCA, RASA1, RHOA, STAT1, STAT3, STAT5A. |
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