细胞循环PCR芯片可用于研究参与细胞循环调控的84个关键基因的表达。这一芯片包含了参与细胞周期、周期转换、DNA复制，以及细胞循环过程中正调控和负调控的基因。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测细胞循环相关基因的表达。
G1 Phase and G1/S Transition: ANAPC2, CCND1, CCNE1, CDC25A, CDC34, CDK4, CDK6, CDKN1B (p27KIP1), CDKN3, CUL1, CUL2, CUL3, E2F1, SKP2. S Phase and DNA Replication: ABL1, CDC6, MCM2, MCM3, MCM4, MCM5, WEE1. G2 Phase and G2/M Transition: ANAPC2, BCCIP, BIRC5, CCNA2, CCNB1, CCNG1, CCNH, CCNT1, CDC25A, CDK5R1, CDK5RAP1, CDK7, CDKN3, CKS1B, CKS2, GTSE1, KPNA2, MNAT1, SERTAD1. M Phase: AURKB, CCNB2, CCNF, CDC25C, CDC6, CDK1 (CDC2), CDC16, CDC20, MRE11A, RAD51, STMN1. Cell Cycle Checkpoint and Cell Cycle Arrest: ATM, ATR, BRCA1, BRCA2, CASP3, CCNA2, CCNG2, CDC25A, CDC25C, CDC34, CDK1 (CDC2), CDK2, CDKN1A (p21CIP1/WAF1), CDKN1B (p27KIP1), CDKN2A (p16INK4), CDKN2B (p15INK4B), CDKN3, CHEK1, CHEK2 (RAD53), CUL1, CUL2, CUL3, GADD45A, HUS1, KNTC1, MAD2L1, MAD2L2, MDM2, NBN (NBS1), RAD1, RAD17, RAD9A, RB1, RBBP8, TP53, WEE1. Regulation of Cell Cycle: ABL1, ANAPC2, ATR, AURKA, BCCIP, BCL2, BRCA2, CCNB1, CCNB2, CCNC, CCND1, CCND2, CCND3, CCNE1, CCNF, CCNH, CCNT1, CDC16, CDC20, CDC25C, CDC6, CDK1 (CDC2), CDK2, CDK4, CDK5R1, CDK6, CDK7, CDK8, CDKN1A (p21CIP1/WAF1), CDKN1B (p27KIP1), CKS1B, E2F1, E2F4, GADD45A, KNTC1, MKI67, RAD9A, RB1, SKP2, TFDP1, TFDP2, WEE1. Negative Regulation of Cell Cycle: ATM, BRCA1, CASP3, CDKN2B (p15INK4B), RBL1, RBL2, TP53. |
