Human DNA Repair DNA Methylation PCR Array, Signature Panel:
EAHS-421Z |
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| The Human DNA Repair EpiTect Methyl II Signature PCR Array profiles the promoter methylation status of a panel of 22 promoters of genes involved in DNA repair pathways such as base excision repair, nucleotide excision repair, mismatch repair, and double-strand break repair. Hypermethylation-based silencing of these genes (BRCA1) increases mutation rates and tumor progression through the carcinogenic process. Profiling cellular or fresh tissue genomic DNA samples with these arrays may help correlate CpG island methylation status with biological phenotypes. The results may also help provide further insights into the role dysregulated DNA repair plays in diseases like cancer. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the promoter methylation status of 22 different genes involved in DNA repair with this DNA methylation PCR array.
Both 96-well and 384-well ( 4 X 96 ) formats are available.
The EpiTect Methyl II PCR Arrays use the MethylScreen™ Technology provided under license from Orion Genomics, LLC. |
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Base Excision Repair (BER): APEX1, LIG3, PARP1, POLB, UNG, XRCC1.
Nucleotide Excision Repair (NER): CCNH, RAD23A, RAD23B, XPC.
Mismatch Repair (MMR): MLH1, MLH3, MSH2, PMS2, POLD3.
Double-Strand Break (DSB) Repair: BRCA1, BRCA2, FEN1, MRE11A, RAD50, RAD51.
Other Genes Related to DNA Repair: ATM. |
