细胞能动性PCR芯片 Cell Motility PCR Array
细胞能动性PCR芯片可用于分析参与细胞运动的84个关键基因的表达。许多细胞依赖细胞运动开展生物过程，如发育、感染和损伤反应。生物刺激如生长因子的释放，会诱导特定的细胞迁移，从而使激活肌动蛋白细胞骨架。肌动蛋白细胞骨架受Rho GTPase家庭调控，能介导细胞的运动，或影响成熟细胞发育过程，如轴突。细胞能通过粘附蛋白运动，从血管内皮的间质白细胞的滚动迁移，到沿着细胞外基质的成纤维细胞的运动，都是通过黏附蛋白发生的。这一芯片包含了生长因子和受体趋化的重要受体基因，参与Rho家族信号通路的粘附分子基因，以及编码各种细胞组件的基因。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测细胞能动性相关基因的表达。 Chemotaxis: FGF2, ITGB2, MAPK1 (ERK2), MYH10, MYH9, PLAUR (uPAR), PLD1, PRKCA, RAC2, TGFB1, VEGFA, WASF2, WIPF1. Receptors: EGFR, IGF1R, ITGA4, ITGB1, ITGB2, ITGB3, MET, PLAUR (uPAR), RHO. Growth Factors: CSF1 (MCSF), EGF, FGF2, HGF, IGF1, TGFB1, VEGFA. Rho Family GTPases: Rho Signaling: ACTR2, ACTR3, ARHGDIA, LIMK1, MSN, MYL9, MYLK, PLCG1, PLD1, PRKCA, PTEN, PTPN1, RHO, RHOA, RHOB, RHOC, RND3, ROCK1, VIM. Rac Signaling: ACTR2, ACTR3, BAIAP2, CFL1, CRK, PAK1, PAK4, PLD1, PRKCA, RAC1, RAC2, STAT3, WASF1, WASF2, WASL. Cdc42 Signaling: ACTR2, ACTR3, CDC42, PFN1, WASF1, WASF2, WASL. Adhesion: Cell-Cell Adhesion: DPP4, EGFR, EZR, ITGA4, ITGB1, ITGB2, MSN, MYH9, ROCK1, TGFB1. Cell-Matrix Adhesion: ACTN1, ACTN3, CSF1 (MCSF), ILK, ITGB1, ITGB2, ITGB3, MMP14, PTEN, PTK2B, PXN, RASA1, RHOA. Focal Adhesion: ACTN1, ACTN3, ARHGEF7, BCAR1, CAPN1, CAPN2, CAV1, ENAH, ILK, ITGB1, MYL9, PTK2, PTK2B, PXN, TLN1, VASP, VCL. Leukocyte Adhesion & Rolling: EZR, ITGA4, ITGB1, ITGB2, MSN, ROCK1. Integrin-Mediated Signaling: BCAR1, ILK, ITGA4, ITGB1, ITGB2, ITGB3, MYH9, PTK2. Cellular Projections: Filopodia: BAIAP2, CDC42, DIAPH1, EGFR, ENAH, EZR, MSN, RDX, SVIL, VASP. Lammelipodia: CTTN, DPP4, EGFR, ENAH, FAP, PIK3CA (p110a), PLD1, PTK2, PXN, RDX, SVIL, VASP, VCL, WASF1, WASF2, WASL. Stress Fibers: ACTN4, DIAPH1, MYH10, MYH9, RHOA, RHOB, RHOC. Membrane Blebs: ACTN1, ACTN3, ACTN4, EZR, MYH10, MYH9, MYLK, RND3, ROCK1. Invasive Projections: ACTR2, ACTR3, ARF6, CDC42, CFL1, CTTN, DPP4, EGF, EZR, FAP, MMP14, MMP2 (Gelatinase A), MMP9 (Gelatinase B), MSN, MYH9, PLAUR (uPAR), RAC2, RASA1, SH3PXD2A, SRC, SVIL, TGFB1, VEGFA, WASL, WIPF1. Growth Cones: ARHGEF7, CDC42, CFL1, PTK2B. Membrane Ruffles: ACTR2, ACTR3, ARF6, BAIAP2, BCAR1, CTTN, DIAPH1, EZR, ITGB1, MYH9, RAC1, RAC2, RDX, RHOA, TLN1, WASF2. Cell Polarity: CDC42, CFL1, EZR, IGF1R, ILK, MYH9. Proteolysis: AKT1, CAPN1, CAPN2, DPP4, FAP, HGF, MMP14, MMP2 (Gelatinase A), MMP9 (Gelatinase B), MYH9, PLAUR (uPAR), TIMP2. |
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