阿尔兹海默症PCR芯片 Alzheimer’s Disease PCR Array
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阿尔兹海默症PCR芯片包含了84个可用于研究老年痴呆症发生与发展的重要基因。芯片中包括与β-淀粉样蛋白（Aβ）的产生、清除和降解有关的基因，还包括β-淀粉样蛋白（Aβ）信号转导途径中参与神经毒性和炎症反应的基因。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测阿尔兹海默症相关基因的表达。
Beta-Amyloid Generation, Oligomerization, Clearance, & Degradation: Secretases: ADAM9, APH1A, BACE1, BACE2, CTSB, NCSTN, PSEN1, PSEN2. Other Peptidases: IDE, PLAT (tPA), PLAU (uPA), PLG. Endocytosis: APLP1, APP, LRP1, LRP6, LRP8. Other Genes: A2M, ACHE, APBB1, APBB2, APOE, BCHE, UBQLN1. Cytoskeleton Reorganization: APOE, MAP2, MAPT, PKP4, PRKCI. Synaptic Formation: ACHE, APBA1, APBB1, APBB2, APOE, BDNF, CHAT. Lipid Metabolism: ABCA1, APOA1, APOE, CLU, HSD17B10 (HADH2), INS, LPL, LRP1, LRP8, SNCB. Apoptosis: APLP1, APP, CASP3, CASP4, CLU, EP300, ERN1, IL1A, MAPT, MPO, NAE1, PRKCA, PRKCE , PRKCZ, PSEN1, PSEN2, SNCA. Cell Cycle: APBB1, APBB2, CDK1 (CDC2), CDK5, CDKL1, ERN1, EP300, IL1A, NAE1, PRKCA. Cell Signaling Molecules: WNT Signaling: GSK3A, GSK3B, LRP6. Notch Signaling: ADAM10, APH1A, NCSTN, PSEN1, PSEN2. G-protein Coupled Receptor Signaling: APLP2, GNAO1, GNAZ, GNB1, GNB4, GNB5, GNG11, GNG3, GNG4, GNGT1, GNGT2, NTRK1, NTRK2. Intracellular Signaling: APBA3, APBB2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCI, PRKCQ, PRKCZ, PSEN1, PSEN2. Other Genes: GAP43, GNB2, IDE, IL1A, INSR, NAE1, PLAU (uPA). Transcription: APBB1, APBB2, EP300, ERN1. Oxidative Stress: HSD17B10 (HADH2), MPO, UQCRC1, UQCRC2. Proteases & Inhibitors: ADAM10, APLP2, APP, CAPN1, CTSC, CTSD, CTSG, CTSL1, SERPINA3, UQCRC2. |
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