DNA修复甲基化PCR芯片 DNA Repair EpiTect Methyl qPCR Array
DNA修复甲基化PCR芯片 DNA Repair EpiTect Methyl qPCR Array
DNA修复甲基化PCR芯片 DNA Repair EpiTect Methyl qPCR Array
运费 ￥0.00
DNA Repair EpiTect Methyl qPCR Array DNA修复甲基化PCR芯片
The Human DNA Repair EpiTect Methyl II Signature PCR Array profiles the promoter methylation status of a panel of 22 promoters of genes involved in DNA repair pathways such as base excision repair, nucleotide excision repair, mismatch repair, and double-strand break repair. Hypermethylation-based silencing of these genes (BRCA1) increases mutation rates and tumor progression through the carcinogenic process. Profiling cellular or fresh tissue genomic DNA samples with these arrays may help correlate CpG island methylation status with biological phenotypes. The results may also help provide further insights into the role dysregulated DNA repair plays in diseases like cancer. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the promoter methylation status of 22 different genes involved in DNA repair with this DNA methylation PCR array. Both 96-well and 384-well ( 4 X 96 ) formats are available. The EpiTect Methyl II PCR Arrays use the MethylScreen™ Technology provided under license from Orion Genomics, LLC. DNA修复甲基化PCR芯片用于研究DNA修复途径如基本切除修复,核苷酸切除修复，错配修复,双链断裂修复等相关的22个基因的启动子甲基化状态。这些基于甲基化沉默的基因(BRCA1)通过致癌过程增加突变率和肿瘤进展。利用这些芯片分析细胞或新鲜组织基因组DNA样本有助于关联CpG岛甲基化状态与生物表型。结果也可以帮助进一步洞察DNA修复在癌症等疾病种异表达的作用利用这个芯片，通过简单的限制性内切酶消化和实时定量PCR，就可以研究分析22个不同的DNA修复相关基因的启动子甲基化状态。 提供96-孔板和384-孔板( 4 X 96 )。 Base Excision Repair (BER): APEX1, LIG3, PARP1, POLB, UNG, XRCC1. Nucleotide Excision Repair (NER): CCNH, RAD23A, RAD23B, XPC. Mismatch Repair (MMR): MLH1, MLH3, MSH2, PMS2, POLD3. Double-Strand Break (DSB) Repair: BRCA1, BRCA2, FEN1, MRE11A, RAD50, RAD51. Other Genes Related to DNA Repair: ATM |
- 姓名
- 电话号码
- 电子邮箱
- 公司名称
- 地址
- 留言*
