阿尔兹海默症PCR芯片 Alzheimer’s Disease PCR Array
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Beta-Amyloid Generation, Oligomerization, Clearance, & Degradation: Secretases: ADAM9, APH1A, BACE1, BACE2, CTSB, NCSTN, PSEN1, PSEN2. Other Peptidases: IDE, PLAT (tPA), PLAU (uPA), PLG. Endocytosis: APLP1, APP, LRP1, LRP6, LRP8. Other Genes: A2M, ACHE, APBB1, APBB2, APOE, BCHE, UBQLN1. Cytoskeleton Reorganization: APOE, MAP2, MAPT, PKP4, PRKCI. Synaptic Formation: ACHE, APBA1, APBB1, APBB2, APOE, BDNF, CHAT. Lipid Metabolism: ABCA1, APOA1, APOE, CLU, HSD17B10 (HADH2), INS, LPL, LRP1, LRP8, SNCB. Apoptosis: APLP1, APP, CASP3, CASP4, CLU, EP300, ERN1, IL1A, MAPT, MPO, NAE1, PRKCA, PRKCE , PRKCZ, PSEN1, PSEN2, SNCA. Cell Cycle: APBB1, APBB2, CDK1 (CDC2), CDK5, CDKL1, ERN1, EP300, IL1A, NAE1, PRKCA. Cell Signaling Molecules: WNT Signaling: GSK3A, GSK3B, LRP6. Notch Signaling: ADAM10, APH1A, NCSTN, PSEN1, PSEN2. G-protein Coupled Receptor Signaling: APLP2, GNAO1, GNAZ, GNB1, GNB4, GNB5, GNG11, GNG3, GNG4, GNGT1, GNGT2, NTRK1, NTRK2. Intracellular Signaling: APBA3, APBB2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCI, PRKCQ, PRKCZ, PSEN1, PSEN2. Other Genes: GAP43, GNB2, IDE, IL1A, INSR, NAE1, PLAU (uPA). Transcription: APBB1, APBB2, EP300, ERN1. Oxidative Stress: HSD17B10 (HADH2), MPO, UQCRC1, UQCRC2. Proteases & Inhibitors: ADAM10, APLP2, APP, CAPN1, CTSC, CTSD, CTSG, CTSL, SERPINA3, UQCRC2 |
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