细胞坏死PCR芯片 Necrosis PCR Array
细胞坏死PCR芯片可用于研究与细胞坏死相关的84个关键基因的表达。细胞坏死（也被称为坏死性凋亡，编程性坏死，胀亡或三型细胞死亡）最近被证明是一个受特定调控的细胞过程。通过丝氨酸/酪氨酸激酶RIPK1活化的死亡受体包括（FAS，TNRSF1A以及TNFRSF10A）。RIPK1 和RIPK3以及活化的PARP1相互作用导致一些线粒体相关的效应没，比如：活性氧种类（ROS）的增加，细胞溶质钙的增加以及ATP的缺失。这张芯片包括程序性坏死相关的基因，死亡受体相信号，ROS的产生或线粒体活性。细胞坏死和调亡可以激活相同的死亡受体，因此，芯片上还包括细胞死亡程序的下游效应分子，从而可以发现细胞坏死的新的分子机制。利用实时定量PCR，研究者可以方便并且可信地对与细胞程序性坏死相关的基因进行同时检测。 Necrosis: Regulation of Necrosis: FAS (TNFRSF6), FASLG (TNFSF6), RIPK1, SLC25A4, TNF. Required for TNF-Induced Necrosis: ATP6V1G2, BMF, C1orf159, CCDC103, COMMD4, CYLD, DEFB1, DENND4A, DPYSL4, EIF5B, FOXI1, GALNT5, GRB2, HSPBAP1, JPH3, KCNIP1, MAG, OR10J3, PARP2, PVR, RAB25, S100A7A, SPATA2, SYCP2, TMEM57, TXNL4B. Other Necrosis Genes: CD40 (TNFRSF5), FADD, MGEA5, RIPK1, RIPK3, PARP1 (ADPRT1), PPIA, SP1, TMEM123. Potential Necrosis Genes: RIPK1 Interactors: FUS, NFKB1, RIPK2, RIPK3. RIPK3 Interactors: GLUD1, GLUL, PYGL, RIPK1. PARP1 Interactors: CAPN1, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPNS1, PPID. Death Domain Receptors: FAS (TNFRSF6), TNFRSF1A (TNFR1), TNFRSF10A (TRAIL-R). Death Receptor Signaling: BID, BIRC3 (c-IAP1), CASP8AP2, CYLD, EDA2R, FADD, FAF1, FEM1B, IKBKG, LRDD (PIDD), MADD, MYD88, NGF, NGFR, NGFRAP1, PARP1 (ADPRT1), RIPK1, TNFRSF14, TNFRSF17, TNFRSF1B, TNFRSF25 (DR3), TNFRSF4 (OX40), TNFRSF8, TNFSF15, TRADD, TRAF2. Apoptosis: Pro-Apoptosis: AIFM1 (PDCD8), BAX, BID, BMF, BNIP3L, CASP8AP2, FADD, FAF1, FAS (TNFRSF6), FASLG (TNFSF6), FEM1B, IKBKG, LRDD (PIDD), MADD, NGFR, NGFRAP1, RIPK1, RIPK2, RIPK3, TNF, TNFRSF10A (TRAIL-R), TNFRSF25 (DR3), TNFRSF8, TNFSF10 (TRAIL), TRADD, TRAF2. Anti-Apoptosis: BIRC3 (c-IAP1), BNIP3L, FAS (TNFRSF6), MYD88, NFKB1, NGF, NGFR, RIPK1, RIPK2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF4 (OX40), TRAF2. Required for TNF-Induced Apoptosis: ATP6V1G2, CYLD, SPATA2, SYCP2. Reactive Oxygen Species (ROS) Activity: AIFM1 (PDCD8), CYBB, GLUD1, NOX1, NOX4. Mitochondrial Genes: AIFM1 (PDCD8), BAX, BID, BNIP3L, CYBB, GLUD1, GLUL, PPID, RIPK1, SLC25A4 |
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