黄斑变性PCR芯片 Macular Degeneration PCR Array
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类黄斑变性PCR芯片可用于研究与老年性黄斑变性（AMD）相关的84个基因的表达。ADM是一类眼科疾病，其分子机制有待进一步研究。该芯片上包含有炎症以及表皮细胞血管生成相关的标志物以及AMD脉络膜小疣标志物，玻璃膜以及视网膜畸形的关键基因。利用实时定量PCR，研究者可以方便并且可信地对与老年性黄斑变性相关的基因进行同时检测。
Anti-angiogenesis: SERPINE1 (PAI-1), SERPINF1, SERPING1. Brusch's membrane markers: FN1, MMP2, MMP9, TIMP1, TIMP3. Choroidal Neovascularization: IGF1, TGFB1, VEGFA. Drusen Markers: APOE, C2, C3, C5, C9, CFB (BF), CFH, CFHR3, CFI, HMOX1, LIPC, TF, VTN. Endothelial Function: ANXA5, CLU, COL14A1, CTGF, EFEMP1, ELN, FBLN5, ICAM1, NOS3 (eNOS), VCAM1, VIM, VWF. Inflammatory Markers: CCL2 (MCP-1), IL6, IL8, PLG, TLR3, TLR4. Oxidative Stress: DICER1, GSTM1 (MGST1), GSTP1, HIF1A, HMOX2, NOS1 (nNOS), SOD2. Retinal Pigment Epithelium Markers: CCL11 (Eotaxin), CRP, CRYAA, CRYAB, CRYGD, CX3CR1, CXCL12 (SDF1), FASLG (TNFSF6), RHO, RLBP1, RPE65, SAG. Other AMD-related Genes: ABCA1, ABCA4, ACE, ALB, ARMS2, CETP, CP, CST3, CTSD, ERCC6, FANCG, GFAP, HMCN1, HTRA1, LEP, LPL, PON1, SCARB1, SLC4A1, SPARC, STMN1, THY1, VLDLR. |
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