炎症反应与自身免疫PCR芯片(96孔)可检测与炎症反应和自身免疫炎症反应相关的84个关键基因的表达。芯片可以分析炎症细胞因子和趋化因子,以及它们受体的基因表达。芯片还包含细胞因子代谢相关的基因,细胞因子及其受体相互作用相关的基因。另外,还包括了急性期反应、炎症反应和体液免疫应答等相关的基因。通过实时定量PCR的方法,研究者即能够利用该芯片简单可靠地同时检测炎症和自身免疫相关的基因表达。 Cytokines: Chemokines: CCL11 (Eotaxin), CCL13 (MCP-4), CCL16 (HCC4), CCL17 (TARC), CCL19, CCL2 (MCP-1), CCL21 (MIP-2), CCL22 (MDC), CCL23 (MPIF-1), CCL24 (Eotaxin-2), CCL3 (MIP-1A), CCL4 (MIP-1B), CCL5 (RANTES), CCL7 (MCP-3), CCL8 (MCP-2), CXCL1, CXCL10 (INP10), CXCL2, CXCL3, CXCL5 (ENA78/LIX), CXCL6 (GCP-2), CXCL9 (MIG). Interleukins: IL10, IL15, IL17A, IL18, IL1A, IL1B, IL1RN, IL22, IL23A, IL5, IL6, IL8. Other Cytokines: CD40LG (TNFSF5), CSF1 (MCSF), FASLG (TNFSF6), IFNG, LTA (TNFB), LTB, TNF, TNFSF14. Cytokine Receptors: Cytokine Receptors: IL10RB, IL1R1, IL1RAP, IL23R, IL6R. Chemokine Receptors: CCR1, CCR2, CCR3, CCR4, CCR7, CXCR1 (IL8RA), CXCR2 (IL8RB), CXCR4. Cytokine Metabolism: IL10, IL18, TLR1, TLR3, TLR4, TLR6. Cytokine-Mediated Signaling Pathway: CCL2 (MCP-1), CCL5 (RANTES), CCR1, CCR2, IFNG, IL1A, IL1B, IL1R1, IL1RN, IL5, IL6, IL6R, MYD88, RIPK2, TNF. Acute-Phase Response: CCL5 (RANTES), CEBPB, CRP, IL1A, IL1B, IL1RN, IL22, IL6, IL6R, PTGS2 (COX2), TNF. Chronic Inflammatory Response:CCL11 (Eotaxin), CCL5 (RANTES), IL1B, LTA (TNFB), TNF. Regulation of Inflammatory Response: BCL6, C3, C3AR1, CCL13 (MCP-4), CCL16 (HCC4), CCL17 (TARC), CCL19, CCL2 (MCP-2), CCL21 (MIP-2), CCL22 (MDC), CCL23 (MPIF-1), CCL24 (Eotaxin-2), CCL3 (MIP-1A), CCL4 (MIP-1B), CCL7 (MCP-3), CCL8 (MCP-2), CCR1, CCR2, CCR3, CCR4, CCR7, CD14, CD40 (TNFRSF5), CD40LG (TNFSF5), CXCL1, CXCL10 (INP10), CXCL2, CXCL3, CXCL5 (ENA78/LIX), CXCL6 (GCP-2), CXCL9 (MIG), CXCR1 (IL8RA), CXCR2 (IL8RB), FOS, IL10, IL10RB, IL1R1, IL1RAP, IL8, IL9, ITGB2, KNG1, LY96 (MD-2), MYD88, NFKB1, NOS2 (iNOS), NR3C1 (GRL), RIPK2, SELE, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR9, TOLLIP. Humoral Immune Response: C3, CCL16, CCL2 (MCP-1), CCL22 (MDC), CCL3 (MIP-1A), CCL7 (MCP-3), CCR2, CCR7, CD40 (TNFRSF5), IL10, IL18, IL1B, IL6, ITGB2, LY96 (MD-2), NFKB1 |