肺癌PCR芯片 Lung Cancer PCR Array
肺癌PCR芯片可用于研究与肺癌发展中关键的84个基因的表达。肺癌与吸烟、环境中的有害气体以及病毒感染有关，但其中的分子机制还需要进一步研究。一些癌症相关的基因调控了免疫反应，调亡，细胞周期，PI3K/AKT以及细胞黏附相关的通路。该芯片包含肺癌样品中常规检测的基因，启动子发生甲基化变化的基因以及和肿瘤转移相关的基因。利用实时定量PCR，研究者可以方便并且可信地对与肺癌发生发展以及转移相关的基因进行同时检测。 Differentially Methylated Promoters: APBA1, APC, CADM1, CDH1, CDH13, CDKN1C, CDKN2A, CDKN2B, CXCL12, CYP1B1, DLC1, FHIT, MGMT, MLH1, MTHFR, OPCML, PRDM2, RASSF1, RASSF2, SFRP1, TCF21. Metastatic Potential: ANXA5, DUSP6, ERBB3, HGF, HMMR, IRF4, LCK, MET, MMD, NF1, STAT1, STAT2. Differentially Expressed Genes in Adenocarcinoma (AC) Versus Squamous Cell Carcinoma (SCC): Higher in AC than in SCC: CLCA2, DSG3, KRT5, KRT14, SPRR1A. Higher in SCC than in AC: AGR2, LGSN, NKX2-1,SFTA3, SPINK1. Up-Regulated in Lung Cancer: CEACAM5, COL11A1, CP, CXCL13, GREM1, MKI67, MMP1, MMP12, SPINK1, SPP1, TOP2A, TOX3. Down-Regulated in Lung Cancer: AGER, CA4, CLDN18, CLIC5, FABP4, GPM6A, SCGB1A1, SFTPC, SOSTDC1, WIF1. PI3K/AKT Signaling: AKT1, BCL2, CDH1, CDKN2A, EGFR, NFKB1, TP53, VEGFA. Apoptosis: ANXA5, APC, BCL2, BIRC5, BRAF, CADM1, CDH1, CDH13, CDKN2A, DLC1, EGFR, ERBB2, ERBB3, HGF, HRAS, KRAS, LCK, MLH1, MMP9, NF1, NFKB1, PTGS2, SFRP1, STAT1, TERT, TGFB1, TNF, TOP2A, TP53, VEGFA. Cell Cycle Regulation: APC, BCL2, BIRC5, CDKN1C, CDKN2A, CDKN2B, EGFR, PTGS2, RB1, TGFB1, TNF, TP53. Immune Response: BCL2, CADM1, CSF3, CXCL12, CXCL13, IRF4, LCK, MLH1, MMD, NFKB1, PAX5, STAT1, STAT2, TGFB1, TNF, TP53, VEGFA. Extracellular Matrix & Cell Adhesion: CADM1, CDH1, CDH13, CEACAM6, CLDN18, COL11A1, DSG3, GPM6A, HMMR, KRT14, KRT5, MET, MMP1, MMP12, MMP9, SFTA3, SFTPC |
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