抗细菌反应PCR芯片 Antibacterial Response PCR Array
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抗细菌反应PCR芯片可用于研究参与细菌先天免疫反应的84个关键基因的表达。三个不同家族模式识别受体（TLRs、NLRS、RIG-I样受体）能启动先天免疫，从而识别常见病原体如细菌等。TLRs、NLRS和其它PRRS可以识别细菌病原体的特征分子，如脂多糖（LPS）、肽聚糖和鞭毛。PAMP受体结合并激活先天免疫反应，启动下游信号，并诱导炎性细胞因子的表达。免疫细胞和上皮细胞分泌的抗菌肽对先天免疫应答也有帮助。它们可以作为免疫细胞的趋化因子，直接破坏病原体的细胞膜，同时激活PRR信号通路。这一芯片包含了参与细菌活性PRR信号转导的基因，对炎症和细胞凋亡有重要作用的下游效应蛋白的基因，和在免疫细胞表达的抗菌肽基因。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测抗细菌反应相关基因的表达，研究对细菌病原体的先天免疫的机制。
Toll-like Receptor (TLR) Signaling: Receptors & Cofactors: CD14, LY96 (MD-2), TLR1, TLR2, TLR4, TLR5, TLR6, TLR9. MYD88-Dependent: FADD, IRAK1, IRAK3, IRF5, IRF7, MAP3K7 (TAK1), MYD88, TIRAP, TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, TOLLIP, TRAF6. TICAM1 (TRIF) Dependent (MYD88-Independent): IRF5, IRF7, MAP3K7 (TAK1), RIPK1, TICAM1 (TRIF), TICAM2 (TRAM), TLR4, TRAF6. Other: AKT1, CASP8 (FLICE), LBP, PIK3CA (p110a), RAC1. NOD-like Receptor (NLR) Signaling: Receptors: NAIP (BIRC1), NLRC4 (IPAF), NLRP1, NLRP3, NOD1 (CARD4), NOD2. Inflammasomes: CASP1 (ICE), NAIP (BIRC1), NLRC4 (IPAF), NLRP1, NLRP3, PYCARD (TMS1/ASC). Regulation: BIRC3 (c-IAP1), CARD6, CARD9, CASP8 (FLICE), HSP90AA1, MEFV, PSTPIP1,RIPK2, SUGT1, TNF, XIAP. Other Bacterial Pattern Recognition Receptors (PRRs): APCS, CRP, DMBT1, ZBP1. Downstream Signal Transduction: NF?B Pathway: CHUK (IKKa), IKBKB, NFKB1, NFKBIA (IkBa/MAD3), RELA, TNFRSF1A. ERK Pathway: JUN, MAP2K1 (MEK1), MAPK1 (ERK2), MAPK3 (ERK1). p38/JNK Pathway: JUN, MAP2K3 (MEK3), MAP2K4 (JNKK1), MAPK14 (p38 MAPK), MAPK8 (JNK1). Apoptosis: AKT1, BIRC3 (c-IAP1), CARD6, CARD9, CASP1 (ICE), CASP8 (FLICE), CD14, FADD, IFNB1, IKBKB, IL12A, IL12B, IL1B, IL6, IRAK1, JUN, MAP3K7 (TAK1), MAPK1 (ERK2), MAPK8 (JNK1), MPO, NFKB1, NFKBIA (IkBa/MAD3), PIK3CA, PYCARD, RAC1, RIPK1, RIPK2, TNF, TNFRSF1A, TRAF6. Inflammatory Response: AKT1, APCS, CCL3 (MIP-1A), CCL5 (RANTES), CD14, CRP, CXCL1, CXCL2, IL1B, IL6, IL8, LBP, LY96 (MD-2), LYZ, MEFV, MYD88, NFKB1, NLRC4, NLRP3, NOD1 (CARD4), RAC1, RELA, RIPK2, SLC11A1, TICAM2 (TRAM), TIRAP, TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, TNF, TNFRSF1A, TOLLIP. Cytokines & Chemokines: CCL3 (MIP-1A), CCL5 (RANTES), CXCL1, CXCL2, IFNA1, IFNB1, IL12A, IL12B, IL18, IL1B, IL6, IL8. Antimicrobial Peptides: BPI, CAMP, CTSG, LCN2 (NGAL), LTF, LYZ, MPO, PRTN3, SLPI |
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