同源异形盒（HOX）基因ChIP PCR芯片 Homeobox (HOX) Genes EpiTect ChIP qPCR Array

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同源异形盒（HOX）基因ChIP PCR芯片 Homeobox (HOX) Genes EpiTect ChIP qPCR Array

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简介：	Homeobox (HOX) Genes EpiTect ChIP qPCR Array 同源异形盒（HOX）基因ChIP PCR芯片
提供商：	SAbiosciences
服务名称：	同源异形盒（HOX）基因ChIP PCR芯片
地区：	美国

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Homeobox (HOX) Genes EpiTect ChIP qPCR Array

同源异形盒（HOX）基因ChIP PCR芯片

Product	Species	Technology	Cat. No.
Homeobox (HOX) Genes EpiTect ChIP qPCR Array	Human	Histone Modifications	GH-083A
Homeobox (HOX) Genes EpiTect ChIP qPCR Array	Mouse	Histone Modifications	GM-083A

The Human Homeobox (HOX) Genes EpiTect Chip qPCR Array profiles the histone modification status or “histone code” of 84 HOX genes involved in multicellular organismal development. Histone modifications regulate chromatin structure, regulate gene activity, and contribute to cellular identity. HOX genes encode a group of homeodomain-containing transcription factors, initially described as genes controlling segmental patterning during development, when dramatic changes in the histone code occur. Recently, the importance of homeobox genes and the epigenetic regulation of their expression has been reemphasized by stem cell and cancer researchers. For example, CDX2 transcriptional repression commonly occurs in colon cancer, due to epigenetic histone alterations in its promoter (high H3K4me3 and H3ac with low H3K4me2 and H3K9me3). Although these HOX genes have been grouped according to their established roles in multicellular organismal development, their true function in your cellular systems is waiting to be discovered by you. Using chromatin immunoprecipitation and this real-time PCR Array, you can easily and reliably analyze the histone modification patterns associated with a focused panel of HOX genes.
The EpiTect Chip qPCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.

同源异形盒（HOX）基因ChIP PCR芯片分析多细胞有机体发育84个关键HOX基因的组蛋白修饰状态或组蛋白密码。组蛋白修饰调节染色质结构，调节基因的活性，助于细胞身份识别。HOX基因编码一组包含同源结构域的转录因子,最初被描述为发育过程控制节段性模式。最近,同源框基因的重要性和表观遗传调控, 被干细胞和癌症研究人员再次强调。例如,CDX2转录抑制一般发生在结肠癌,由其启动上表观遗传学组蛋白修饰引起(高H3K4me3和低H3K4me2 H3ac H3K9me3)。虽然这些HOX基因已经被根据它们在多细胞生物发育中扮演的角色进行分类，它们在细胞系统中的真实功能仍待被你发掘。通过染色质免疫沉淀和EpiTect ChIP qPCR芯片，可以很简易、可靠地分析组蛋白的化学修饰模式与HOX基因的关联。

EpiTect ChIP qPCR仅用于分子生物学应用。本产品不用于疾病的诊断、预防和治疗。

Anatomical Structure Morphogenesis: HOXA11, HOXA4, HOXC10, HOXC13, HOXD3, LBX1, PITX1, POU5F1 (OCT4), SIX2, SIX4.
Organ Morphogenesis: CDX1, CDX2, HOXA3, HOXA5, MSX1, PAX3, PDHX, PITX2, PITX3, PROX1, SIX6.
Body Pattern Formation: ALX3, HHEX, HOXA11, HOXA2, HOXA3, HOXA4, HOXA5, HOXB1, LMX1B, PITX2.
Ectoderm Development: PROX1, VAX2.
Endoderm Development: HOXC11.
Brain & Nervous System Development:
Brain Development: ALX1, DLX2, DMBX1, HESX1, HOXA2, OTX2, SIX3.
Nervous System Development: ARX, DLX5, DLX6, LBX1, OTP, PAX3, PHOX2B, PROP1, SHOX2.
Skeletal Development: ALX4, DLX3, DLX5, DLX6, HOXD13, MSX1, MSX2, PITX1, SHOX2.
Muscle Development: MKX, SIX1.
Heart Development: ISL1, SHOX2.
Other HOX Genes Involved In Multicellular Organismal Development: BARX1, CDX4, CUX1, DLX1, DLX4, DRGX, EMX1, EN2, HOXA1, HOXA7, HOXA9, HOXB2, HOXB3, HOXB7, HOXB8, HOXB9, HOXC12, HOXC8, HOXC9, HOXD1, HOXD11, HOXD12, HOXD4, HOXD9, ISL2, LBX2, LMX1A, MEIS1, MEOX1, NKX3-1, OTX1, TLX1, VAX1, VSX1.
HOX Genes Involved In Cell Differentiation: ARX, HHEX, HOPX, LBX1, LMX1B, MIXL1, OTP

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