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Brain Cancer miScript miRNA PCR Array
人脑癌症miRNAPCR芯片The Human Brain Cancer miScript miRNA PCR Array profiles the expression of 84 miRNAs known to alter their expression during nervous system-related carcinogenesis. This array provides cancer researchers with a convenient way to quickly analyze the miRNAs most relevant to brain and central nervous system tumorigenesis. Brain tumors, which cause uncontrolled cellular growth in the cranium or spinal column, involve any of the cell types found in the brain, such as neurons, glial cells, astrocytes, or cells of the meninges.By attenuating gene expression, miRNAs regulate many biological functions, and some, such as those in the miR-17-92 cluster, have known oncogenic properties. Expression studies of different brain tumor types have identified dysregulated miRNA; however, few are functionally linked to pathogenic mechanisms. Research into the functional consequences of miRNA dysregulation during neurocarcinogenesis may yield insights into the molecular mechanisms behind the pathogenesis of brain tumors.The array contains miRNAs with known functional consequences as well as miRNAs with a significant dysregulation but unknown function during oncogenesis. The profiling results from this array may yield insights into the molecular mechanisms behind the pathogenesis of multiple nervous system cancers. A set of controls present on this array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, and assessment of PCR performance. Using SYBR Green-based real-time PCR, the expression of a focused panel of miRNAs related to brain cancer can be easily and reliably analyzed with this miScript miRNA PCR Array.
miScript miRNA PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention or treatment of a disease.
96-well, 384-well ( 4 x 96 ), and Rotor-Disc 100 formats are available.
人大脑癌症miRNAPCR芯片用于分析在神经系统相关的致癌作用中发生表达变异的84 个miRNA的表达。这个芯片为癌症研究人员提供了一个方便的方法来快速分析大脑和中枢神经系统肿瘤发生最相关的miRNA。脑部肿瘤,导致头盖骨和脊柱的细胞增长不受控制，涉及任大脑中发现的何细胞类型，如神经元、神经胶质细胞、星形胶质细胞或细胞脑膜。通过衰减基因表达，miRNA调节许多生物功能和一些比如在miR-17-92 cluster中已知的致癌特性。不同的脑部肿瘤类型的表达研究已经发现了miRNA表达的异常，然而其功能与致病机制了解很少。这个芯片包含功能已知的及在肿瘤形成中严重失调但功能未知的miRNA。这个芯片的分析结果可能在多种神经系统癌症背后的发病机理产生更深入的了解。每张芯片含一个对照组使得分析数据时可以用相对定量ΔΔCT方法评估逆转录效率,基因组DNA污染,和PCR效率。利用这张芯片，通过实时定量PCR，可以简易且可靠地分析大脑癌症关键基因集的表达。
miScript miRNA PCR芯片仅用于分子生物学应用。本产品不用于疾病的诊断、预防和治疗。
提供96孔板——384 -(4 x 96)板,和100孔板
Anaplastic Astrocytoma:miR-107, miR-10b-5p, miR-124-3p, miR-125b-5p, miR-127-5p, miR-129-5p, miR-137, miR-138-5p, miR-187-3p, miR-203a, miR-218-5p, miR-296-5p, miR-31-5p, miR-320a, miR-7-5p.
Glioblastoma:miR-101-3p, miR-107, miR-10b-5p, miR-124-3p, miR-128, miR-129-5p, miR-130a-3p, miR-132-3p, miR-133a, miR-133b, miR-137, miR-138-5p, miR-149-5p, miR-153, miR-16-5p, miR-181a-5p, miR-181b-5p, miR-185-5p, miR-187-3p, miR-191-5p, miR-203a, miR-21-5p, miR-210, miR-218-5p, miR-221-3p, miR-222-3p, miR-222-5p, miR-23a-3p, miR-23b-3p, miR-25-3p, miR-29b-3p, miR-31-5p, miR-323a-5p, miR-328, miR-34a-5p, miR-425-5p, miR-451a, miR-486-5p, miR-7-5p.
Glioma:miR-106b-5p, miR-10b-5p, miR-128, miR-130b-3p, miR-144-3p, miR-146b-5p, miR-148a-3p, miR-15a-5p, miR-15b-5p, miR-16-5p, miR-17-5p, miR-181a-5p, miR-181b-5p, miR-182-5p, miR-183-5p, miR-184, miR-19a-3p, miR-200a-3p, miR-20a-5p, miR-21-5p, miR-210, miR-221-3p, miR-222-3p, miR-23a-3p, miR-25-3p, miR-26a-5p, miR-27a-3p, miR-296-5p, miR-328, miR-34a-5p, miR-451a, miR-486-5p, miR-9-5p, miR-9-3p, miR-93-5p.
Medulloblastoma:miR-106b-5p, miR-124-3p, miR-125a-5p, miR-125b-5p, miR-127-5p, miR-128, miR-129-5p, miR-130a-3p, miR-130b-3p, miR-133b, miR-137, miR-138-5p, miR-148a-3p, miR-150-5p, miR-153, miR-17-92 cluster (miR-17-5p, miR-18a-5p, miR-19a-3p, miR-20a-5p, miR-19b-3p, miR-92a-3p), miR-17-3p, miR-187-3p, miR-190a, miR-191-5p, miR-203a, miR-210, miR-216a-5p, miR-217, miR-218-5p, miR-25-3p, miR-29a-3p, miR-29b-3p, miR-30b-5p, miR-30c-5p, miR-320a, miR-323a-5p, miR-324-5p, miR-326, miR-328, miR-331-5p, miR-335-5p, miR-34a-5p, miR-425-5p, miR-7-5p, miR-9-3p, miR-93-5p, miR-96-5p.
Meningioma:let-7b-5p, miR-106a-5p, miR-106b-5p, miR-125a-5p, miR-153, miR-15a-5p, miR-181a-5p, miR-185-5p, miR-19b-3p, miR-200a-3p, miR-217, miR-23b-3p, miR-26a-5p, miR-27a-3p, miR-29a-3p, miR-335-5p, miR-451a.
Neuroblastoma:let-7b-5p, miR-106a-5p, miR-107, miR-125a-5p, miR-125b-5p, miR-128, miR-129-5p, miR-137, miR-141-3p, miR-146a-5p, miR-149-5p, miR-150-5p, miR-17-3p, miR-181a-5p, miR-181b-5p, miR-184, miR-187-3p, miR-190a, miR-200a-3p, miR-216a-5p, miR-221-3p, miR-23b-3p, miR-24-3p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-30b-5p, miR-30c-5p, miR-320a, miR-323a-5p, miR-324-5p, miR-326, miR-331-5p, miR-335-5p, miR-34a-5p, miR-9-5p, miR-92a-3p, miR-93-5p.
Retinoblastoma:miR-320a
工作原理：
What miScript miRNA PCR Arrays offer?
Guaranteed Performance* - ready-to-use for gene expression analysis
Time & Cost Saving - less than 30 min hands-on time to analyze 84 or 372 miRNA
Simple Data Analysis - easy-to-use Excel-Based Data Analysis Template |
