动脉粥样硬化PCR芯片 Atherosclerosis PCR Array
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动脉粥样硬化PCR芯片可用于研究参与动脉粥样硬化的84的关键基因的表达。芯片包含了参与凝血和循环过程，参与酶和脂质运输及代谢的基因；也包含了应激反应、细胞生长、增殖和凋亡的基因。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测动脉粥样硬化相关基因的表达。 Response to Stress: Inflammatory Response: CCL2, CCL5, CCR1, CCR2, IL1R1, IL1R2, ITGB2, NFKB1, NOS3, SELE, SPP1, TNF. Response to Oxidative Stress: APOE, CCL5, SOD1. Response to Pests, Pathogens or Parasites: CCL2, CCR2, CSF2, FN1, IL4, ITGB2, TNF. Response to Virus: CCL5, IFNAR2, TNF. Response to Wounding: CCR1, CCR2, CTGF, FN1, PDGFB, TNF, VWF. Other Genes Related to Stress Response: IFNG, PPARG, VEGFA. Apoptosis: Anti-apoptosis: BCL2, BCL2A1, BCL2L1, BIRC3, CCL2, CFLAR, FAS (TNFRSF6), IL1A, IL2, NFKB1, SERPINB2, SPP1, TGFB1, TNF, TNFAIP3. Induction of Apoptosis: APOE, BAX, BID, CFLAR, FAS (TNFRSF6). Other Genes Related to Apoptosis: IL5, ITGB2. Blood Coagulation and Circulation: Blood Coagulation: FGA, ITGA2, LPA, SERPINE1. Circulation: APOA1, APOB, APOE, COL3A1, ELN, ENG, LPA, LPL, NPY. Platelet Activation: PDGFA, PDGFB, PDGFRB, VWF. Regulation of Blood Pressure: ACE, FGA. Adhesion Molecules: Cell-cell Adhesion: CD44, CDH5, ICAM1, ITGB2, SELE, SELL, TNF, VCAM1, VEGFA. Cell-matrix Adhesion: CD44, ITGA2, ITGA5, ITGAX, ITGB2, SPP1. Other Genes Involved in Adhesion: CCL2, CCL5, CCR1, CTGF, ELN, ENG, FN1, LAMA1, SELPLG, THBS4, TNC, VWF. Extracellular Molecules: ECM Protease Inhibitors: LPA, SERPINB2, SERPINE1. ECM Proteases: ACE, MMP1, MMP3. Extracellular Matrix (ECM) Structural Constituents: COL3A1, ELN, FN1. Other Extracellular Molecules: ADFP, APOA1, APOB, APOE, CCL2, CCL5, CSF2, CTGF, FGA, FGF2, HBEGF (DTR), IFNAR2, IFNG, IL1A, IL2, IL3, IL4, IL5, LAMA1, LIF, LPL, NPY, PDGFA, PDGFB, SPP1, THBS4, TNC, VEGFA, VWF. Lipid Transport and Metabolism: Cholesterol Metabolism: ABCA1, APOA1, APOB, APOE, IL4, LDLR. Fatty Acid Metabolism: FABP3, LPL, PPARA, PTGS1. Lipid Transport: ABCA1, APOA1, APOB, APOE, FABP3, LDLR, LPA, LPL, MSR1. Lipoprotein Metabolism: APOA1, APOE, LDLR, LPL. Steroid Metabolism: NR1H3, PPARA, PPARD, PPARG, RXRA. Other Genes Related to Lipid Metabolism: PLIN2, APOE, LPA. Cell Growth and Proliferation: Growth Factors and Receptors: CSF2, KDR, PDGFRB, SPP1. Negative Regulation of Cell Proliferation: BCL2, FABP3, IL1A. Positive Regulation of Cell Proliferation: CSF1, FGA, FGF2, HBEGF (DTR), IL2, IL3, IL5, LIF, VEGFA. Regulation of the Cell Cycle: FGF2, IL1A, PDGFA, PDGFB, TGFB1, TGFB2, VEGFA. Other Genes Involved in Cell Growth and Proliferation: CTGF, ELN, IFNG, IL4, NPY. Transcription Regulators: Nuclear Receptors: NR1H3, PPARA, PPARD, PPARG, RXRA. Other Transcription Regulators: EGR1, KLF2, NFKB1, TNF, TNFAIP3. |
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