抗病毒反应PCR芯片 Antiviral Response PCR Array
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抗病毒反应PCR芯片可用于研究参与病毒先天免疫反应的84个关键基因的表达。三个不同家族的模式识别受体（TLRs，NLRS，RIG-I样受体）启动先天免疫，从而识别常见病原体如病毒等。这些受体识别和结合病毒DNA和RNA，激活下游的信号通路，从而诱导炎性细胞因子的表达，如α和β干扰素。这一芯片包含了TLRs信号效应体基因、NLRS基因和RIG-I样受体基因，下游信号通路相关基因，I型干扰素信号通路相关基因，以及干扰素刺激基因（ISGs）。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测抗病毒反应相关基因的表达，研究特定病毒感染环境下，先天免疫信号网络的相互作用。 Toll-Like Receptor Signaling: Receptors and Chaperones: CTSB, CTSL1, CTSS, TLR3, TLR7, TLR8, TLR9. Downstream Signaling: CHUK (IKKa), FOS, IKBKB, IRAK1, IRF3, IRF5, IRF7, JUN, MAP2K1 (MEK1), MAP2K3 (MEK3), MAP3K7 (TAK1), MAPK1 (ERK2), MAPK14 (p38 MAPK), MAPK3 (ERK1), MAPK8 (JNK1), MYD88, NFKB1, NFKBIA (I?Ba/MAD3), RELA, RIPK1, SPP1, TBK1, TICAM1 (TRIF), TNF, TRAF3, TRAF6. Responsive Genes: CCL3 (MIP-1A), CCL5 (RANTES), CD40 (TNFRSF5), CD80, CD86, CXCL10 (INP10), CXCL11 (I-TAC/IP-9), CXCL9 (MIG), IFNA1, IFNA2, IFNB1, IL12A, IL12B, IL15, IL1B, IL6. Nod-Like Receptor Signaling: Receptors and Signaling: AIM2, CARD9, CASP1 (ICE), HSP90AA1, MEFV, NLRP3, NOD2, OAS2, PSTPIP1, PYCARD (TMS1/ASC), PYDC1 (POP1), SUGT1. Responsive Genes: IL1B, IL18. RIG-I-Like Receptor Signaling: Receptors and Chaperones: CYLD, DAK, DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), ISG15 (G1P2), TRIM25. Downstream Signaling: ATG5, AZI2, CASP10 (MCH4), CASP8 (FLICE), CHUK (IKKa), DDX3X, FADD, IKBKB, IRF3, IRF7, MAP3K1 (MEKK1), MAP3K7 (TAK1), MAPK14 (p38 MAPK), MAPK8 (JNK1), MAVS, NFKB1, NFKBIA, PIN1, RELA, RIPK1, TBK1, TNF, TRADD, TRAF3, TRAF6. Responsive Genes: CXCL10 (INP10), IFNA1, IFNA2, IFNB1, IL12A, IL12B, IL8. Type-I-Interferon Signaling and Response: Signaling Pathway: IFNA1, IFNA2, IFNAR1, IFNB1, STAT1. Interferon-Stimulated Genes (ISGs): APOBEC3G, IL15, ISG15 (G1P2), MX1, TLR3. |
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