氧化氮A信号通路PCR 芯片 Nitric Oxide Signaling Pathway PCR Array
氧化氮A信号通路PCR 芯片 Nitric Oxide Signaling Pathway PCR Array
氧化氮A信号通路PCR 芯片 Nitric Oxide Signaling Pathway PCR Array
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一氧化氮A（NO）信号通路RT2 ProfilerTM PCR Array包含了表达受第二信使NO控制及参与NO信号通路的84个基因。NO是参与和抑制疾病发生的动态生物效应分子。NO分子能够可逆地改变特异基因的表达，和许多蛋白的活性以及可逆影响信号通路，从而能够影响许多生理活动。本芯片包括参与NO生物合成、过氧化物代谢的基因和参与氧化应激反应的基因。还包括被NO诱导或抑制的基因，这些基因能够作为细胞体系中NO信号通路激活的指标。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测NO信号通路相关基因的表达。 Nitric Oxide Biosynthesis: Oxidoreductases: NOS1 (nNOS), NOS2 (iNOS), NOS3 (eNOS), NQO1. Nitric Oxide Biosynthesis Regulation: DYNLL1, GLA, HSP90AB1 (HSPCB), IL10, INS, NOS1AP. Other Genes: AKT1, ARG2, DDAH2, DYNLL1, EGFR, GCH1, GCHFR. Genes Induced by Nitric Oxide: CDKN1A (p21CIP1/WAF1), IL8, JUN, VEGFA. Genes Suppressed by Nitric Oxide: CCNA1, MYB, TROAP. Nitric Oxide Signaling Pathway: CAMK1, DLG4 (PSD95), GRIN2D, NOS1 (nNOS), PPP3CA, PRKAR1B, PRKCA. Superoxide Metabolism: Superoxide Release: ALOX12, DUOX1, DUOX2, NOX5, PRG3. Oxidoreductases: ALOX12, DUOX1, DUOX2, NOS2, NOX5, SOD1, SOD2, SOD3. Peroxidases: DUOX1, DUOX2. Other Genes: CCS, NCF1, NCF2, PREX1. Response to Oxidative Stress: Anti-Apoptosis: MPO, MTL5, NME5, PRDX2, RNF7. Antioxidants: APOE, MT3, SELS, SOD1, SOD3, SRXN1. Glutathione Peroxidases: GPX1,GPX2, GPX3, GPX4, GPX5, GPX6. Oxidoreductases: CAT, EPX, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, LPO, MPO, MSRA, PRDX2, PRDX6, SOD1, SOD2, SRXN1, TPO, TXNRD2. Peroxidases: CSDE1, CYGB, EPX, GPR156, LPO, MPO, PRDX2, PRDX5, PRDX6 (AOP2), TPO, TTN. Transcription Regulators: CSDE1, FOXM1, GLRX2, SCRT2, SIRT2, SOD2. Other Genes: ATOX1, DUSP1 (PTPN16), GSS, KRT1, MBL2, NUDT1, OXR1, PNKP, PRNP, SCARA3, SEPP1, SGK2. |
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