NFκB 信号靶标PCR 芯片 NFκB Signaling Targets PCR Array
NFκB 信号靶标PCR 芯片 NFκB Signaling Targets PCR Array
NFκB 信号靶标PCR 芯片 NFκB Signaling Targets PCR Array
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NFκB 信号靶标PCR 芯片可用于研究84个NFκB信号转导应答关键基因的表达。NFκB家族的转录因子，可调节多种细胞过程，包括炎症，免疫和应激反应。IκB抑制剂家族使这些转录因子隔绝在细胞质中。多种配体如各种炎症细胞因子，生长因子及来自病原体的抗原可以激活的NFκB信号通路导致IκB蛋白的磷酸化和去磷酸化。新释放的NFκB转录因子形成有活性的复合物进入细胞核，诱导其靶基因的表达。炎症或自身免疫性疾病可以导致该信号转导通路的失调。通过各种实验技术如表达谱分析、ChIP和转录因子结合位点的生物信息学预测，鉴定得出了大量的NFκB靶标基因。该芯片涵盖了NFκB转录因子和多种实验验证得到的高度相关性靶标基因，芯片结果可用来分析NFκB信号传导的激活或抑制。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测NFκB关联细胞活动相关基因的表达。
Cytokines & Chemokines: CCL11, CCL2 (MCP-1), CCL22 (MDC), CCL5 (RANTES), CSF1 (MCSF), CSF2 (GM-CSF), CSF3 (GCSF), CXCL1, CXCL10 (INP10), CXCL2, CXCL9 (MIG), FASLG (TNFSF6), IFNB1, IFNG, IL12B, IL15, IL1A, IL1B, IL1RN, IL2, IL4, IL6, IL8, LTA (TNFB), LTB, TNF, TNFSF10 (TRAIL). Inflammation: Acute: C3, CCL5 (RANTES), CFB (BF), F3, F8, IL1A, IL1B, IL6, INS, STAT3, STAT5B. Other Inflammatory Genes: AGT, AKT1, CCL11, CCL2 (MCP-1), CCL22 (MDC), CCR5, CD40 (TNFRSF5), CXCL1, CXCL10 (INP10), CXCL2, CXCL9 (MIG), IL15, IL1RN, IL2, IL2RA (CD25), IL8, MYD88, PTGS2 (COX-2), SELE, SELP, TNF, TNFRSF1B. Apoptosis: AGT, BIRC2 (c-IAP2), EGFR, FASLG (TNFSF6), GADD45B, IFNB1, IFNG, IL12B, IL2RA (CD25), IL4, INS, LTA (TNFB), MAP2K6 (MEK6), MMP9 (Gelatinase B), NQO1, NR4A2 (NUR77), PTGS2 (COX-2), STAT1, TNFRSF1B, TNFSF10 (TRAIL), TP53, TRAF2. Anti-Apoptosis: ADM, AKT1, BCL2A1 (BFL-1/A1), BCL2L1 (BCL-X), BIRC3 (c-IAP1), CCL2 (MCP-1), CDKN1A (p21CIP1/WAF1), CSF2 (GM-CSF), F3, FAS (TNFRSF6), IL1A, IL1B, IL2, IL6, MYD88, NFKBIA (IkBa/MAD3), SOD2, STAT5B, TNF, XIAP. Immune Response: Innate: C3, CCL2 (MCP-1), CFB (BF), IFNB1, IL12B, IL6, INS, MYD88, NFKBIA (IkBa/MAD3), STAT5B, TNF. Adaptive: C3, CCL2 (MCP-1), CD40 (TNFRSF5), CD80, ICAM1, IFNG, IL12B, IL1B, IL2, IL4, TRAF2. Other Immunity-Related Genes: CD83, FAS (TNFRSF6), FASLG (TNFSF6), IL1R2, IL8, LTA (TNFB), LTB, TNFSF10 (TRAIL). Type I Interferon-Responsive Genes: ADM, CCL2 (MCP-1), CCL5 (RANTES), CD69, CD80, CDKN1A (p21CIP1/WAF1), CFB (BF), CXCL10 (INP10), CXCL9 (MIG), IL15, IL1RN, IRF1, MYD88, NCOA3, STAT1, TNFSF10 (TRAIL). Development & Differentiation: Lymphoid: CD80, CD83, IL12B, IL15, IL2, IL2RA (CD25), IL4, IRF1, STAT5B, TP53, VCAM1. Myeloid: CCL5 (RANTES), CSF1 (MCSF), CSF2 (GM-CSF), CSF2RB, CSF3 (GCSF), IL4, MMP9 (Gelatinase B), NFKBIA (IkBa/MAD3), STAT5B, TNF. Nervous System: AGT, ALDH3A2, CXCL1, EGFR, EGR2, IFNG, NR4A2 (NUR77), SNAP25, SOD2, STAT3, TP53. Stress Response: ADM, AKT1, BCL2L1 (BCL-X), BIRC2 (c-IAP2), CCND1, CDKN1A (p21CIP1/WAF1), GADD45B, IFNG, IL1A, IL1B, MAP2K6 (MEK6), NQO1, PDGFB, PLAU (uPA), SOD2, TNF, TP53, XIAP. NFkB Pathway: Signal Transduction: NFKB1, NFKB2, NFKBIA (IkBa/MAD3), RELB, STAT1. Regulation: BIRC2 (c-IAP2), CD40 (TNFRSF5), FASLG (TNFSF6), IL1B, MYD88, REL, RELA, TNF, TNFSF10 (TRAIL). Transcription Factors: NFkB Signaling: NFKB1, NFKB2, REL, RELA, RELB. Others: EGR2, IRF1, MYC, NR4A2 (NUR77), STAT1, STAT3, STAT5B, TP53. |
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