乳腺癌PCR芯片 Breast Cancer PCR Array
乳腺癌PCR芯片可用于研究与乳腺癌失调、乳腺癌细胞信号转导，及其他生物过程失调有关的84个关键基因的表达。乳腺癌是一种异质性疾病，在分子层面上可以分为正常乳腺癌样、管腔、HER2像，和基底样（称为三阴性）肿瘤。对致癌机制的深入研究表明，某些基因表达水平的变化将影响细胞信号转导和整个生物通路功能，从而导致癌症发生。通过研究这些失调的基因和已知肿瘤分类标志物即可识别乳腺癌的发生、发展和转移。这一芯片包含了肿瘤分类的标志物基因，肿瘤信号转导相关基因，以及其他相关途径基因，如血管生成、粘附、蛋白水解、细胞周期和细胞凋亡。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测乳腺癌发生相关基因的表达。
Tumor Classification Markers: Luminal A-C: ESR1 (ERa), FOXA1, GATA3, KRT8, KRT18, SLC39A6, TFF3, XBP1. HER2-like: ERBB2 (HER2), GRB7. Basal-like / Triple Negative: BIRC5, EGFR, KRT5, NOTCH1. Metastasis to Lung: ID1, MMP2 (Gelatinase A), PTGS2 (COX2). Signal Transduction: Steroid Receptor-Mediated: AR, BRCA1, CCNE1, CTNNB1, ESR1 (ERa), ESR2 (ERß), IGF1, KRT19, PGR, RB1. Hedgehog: BCL2, CCND1, GLI1, SNAI2. Glucocorticoid: IGFBP3, NME1 (NM23A), NR3C1 (GRL). Classical WNT: APC, CCND1, CTNNB1, SFRP1. PI3K/AKT: AKT1, ERBB2 (HER2), IGF1, IGF1R, PTEN. NOTCH: BIRC5, NOTCH1. MAPK: MAPK1 (ERK2), MAPK3 (ERK1), MAPK8 (JNK1), TP73. Epithelial to Mesenchymal Transition: CTNNB1, NOTCH1, SRC, TGFB1, TWIST1. Angiogenesis: CDH13, CTNNB1, EGF, ERBB2 (HER2), ID1, IL6, JUN, NOTCH1, PLAU (uPA), PTEN, SERPINE1 (PAI-1), SLIT2, THBS1, VEGFA. Adhesion: ADAM23, APC, BCL2, CDH1 (E-Cadherin), CDH13, CDKN2A (p16INK4), CSF1 (MCSF), CTNNB1, EGFR, ERBB2 (HER2), PTEN, TGFB1, THBS1. Proteolysis: ADAM23, CST6, CTSD, MMP2 (Gelatinase A), MMP9 (Gelatinase B), PLAU (uPA), PYCARD (ASC). Apoptosis: AKT1, APC, BAD, BCL2, CDH1 (E-CADHERIN), CDH1 (E-CADHERIN)3, CDKN1A (P21CIP1/WAF1), CDKN2A (p16INK4), GSTP1, IGF1, IL6, JUN, MUC1, NME1 (NM23A), RARB, SFN (14-3-3s), SFRP1, TP53, TP73, TWIST1. Cell Cycle: APC, BCL2, CCNA1, CCND1, CCND2, CCNE1, CDK2, CDKN1A (p21CIP1/WAF1), CDKN1C (p57KIP2), CDKN2A (p16INK4), JUN, MKI67, MYC, PTEN, RASSF1, RB1, SFN (14-3-3s), TP53. DNA Damage: APC, ATM, BRCA1, BRCA2, CCND1, CDKN1A (p21CIP1/WAF1), MAPK1 (ERK2), MGMT (AGT), MLH1, SFN (14-3-3s), TP53, TP73. Xenobiotic Transport: ABCB1 (MDR-1), ABCG2 (BCRP). Transcription Factors: AR, CTNNB1, ESR1 (ERa), ESR2 (ERß), FOXA1, GATA3, HIC1, JUN, MYC, NOTCH1, NR3C1 (GRL), PGR, PRDM2 (RIZ1), RARB, RB1, TP53, TP73, XBP1. |
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